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Best Eye Drops for Sjögren’s Syndrome: A Comprehensive Guide

Sjögren’s syndrome, an autoimmune disorder primarily affecting moisture-producing glands, often leads to dry eyes, a condition known as keratoconjunctivitis sicca. Managing this symptom effectively is crucial for improving the quality of life for those with the syndrome. Eye drops are a frontline treatment for alleviating the discomfort of dry eyes. This guide discusses about dry eye products, especially eye drops, tailored to the needs of Sjögren’s syndrome patients.

Understanding Sjögren’s Syndrome and Dry Eyes

Sjögren’s syndrome causes the immune system to attack the glands that produce tears and saliva. This leads to reduced tear production and, consequently, dry eyes. Symptoms include a gritty or burning sensation, redness, and blurred vision. Over-the-counter and prescription eye drops can help manage these symptoms.

Over-the-Counter Eye Drops

Artificial Tears


Refresh Tears, Systane Ultra, Blink Tears


Artificial tears mimic natural tears and provide immediate relief by lubricating the eyes. They are available in various formulations, including artificial tears preservative-free options, which are ideal for frequent use.


Typically, they can be used multiple times a day as needed.

Lubricating Eye Gels and Ointments


GenTeal Gel, Refresh PM


These are thicker than standard eye drops, providing longer-lasting relief. They are particularly useful for nighttime use as they can blur vision if used during the day.


Usually applied before bed for overnight relief.

Hydroxypropyl Methylcellulose Drops


TheraTears, Bion Tears


These drops increase tear film stability and provide longer-lasting lubrication.


Often used as needed throughout the day.

Prescription Eye Drops

Consult with a doctor if you need prescription eye drops. Telemedicine options are available to fit into your busy schedules.

Cyclosporine (Restasis)


Restasis helps increase tear production by reducing inflammation in the tear glands. It is particularly beneficial for long-term treatment.


Typically prescribed to be used twice daily. It may take a few months to notice significant improvement.

Lifitegrast (Xiidra)


Xiidra is another anti-inflammatory medication that can increase tear production and reduce symptoms of dry eye disease.


Administered twice daily, it often starts to relieve symptoms within a few weeks.

Autologous Serum Eye Drops


These are made from the patient’s blood and contain growth factors and vitamins that promote healing and lubrication of the eye surface.


Typically prescribed by an ophthalmologist and tailored to the patient’s specific needs.

Choosing the Right Eye Drops

Selecting the appropriate eye drops depends on the severity of your symptoms, the frequency of use, and any specific sensitivities. Here are some tips:

Frequency of Use

For frequent use, opt for preservative-free artificial tears to avoid irritation.

Severity of Symptoms

For more severe dryness, thicker gels or ointments might be necessary.

Long-Term Management

Prescription options like Restasis or Xiidra can provide sustained relief and address underlying inflammation.

Additional Tips for Managing Dry Eyes


Using a humidifier can help maintain moisture in the air, especially in dry environments.

Warm Compresses

Applying a warm compress to your eyes can help stimulate tear production and relieve discomfort.


Staying well-hydrated by drinking plenty of water can support overall eye health.


Managing dry eyes associated with Sjögren’s syndrome requires a comprehensive approach, combining the right eye drops with lifestyle modifications. While over-the-counter options provide immediate relief, prescription drops can offer long-term benefits by addressing the root cause of dryness. Always consult with an eye care professional to tailor a treatment plan that best suits your needs. By finding the right combination, you can significantly improve your comfort and quality of life.